Great start of 2017: two papers accepted in Brain and in CNS Neuroscience & Therapeutics!

New paper accepted in Brain

My PhD student Michiel Dirkx investigated how dopamine influences the tremor circuitry in Parkinson’s disease. He found that, surprisingly, dopamine influences a cerebellar portion of the thalamus. Multivariate analyses (dynamic causal modeling) showed that this is not a down-stream effect mediated by the basal ganglia. This finding suggests that altered dopaminergic projections to the cerebello-thalamic system have a role in Parkinson’s tremor.

New paper accepted in CNS Neuroscience & Therapeutics

My PhD student Heidi Zach showed that the anti-tremor effect of levodopa in Parkinson’s disease is reduced during cognitive stress, as compared to normal resting conditions. This suggests that non-dopaminergic mechanisms, possibly the noradrenergic system, “take over” during cognitive stress.

New paper accepted in Parkinsonism & related Disorders

My PhD student Heidi Zach investigated to what extent Parkinson patients’ own opinion on levodopa effectiveness correlates with quantitative and clinical measures. It turns out that there is a stronger patient-clinician agreement for tremor than for bradykinesia/rigidity. Furthermore, there was stronger patient-clinician agreement for tremor under stress than for tremor at rest. This suggests that patients judge the effect of levodopa by its ability to reduce tremor under stress.


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