– H-index: 19 (source: Google Scholar).

Nieuwhof F, Bloem BR, Reelick M.F, Aarts E, Maidan I, Mirelman A, Hausdorff JM, Toni I, Helmich RC. Impaired dual tasking in Parkinson’s disease is associated with reduced focusing of cortico-striatal activity (2017). Brain, in press.

Dirkx MF, den Ouden H, Aarts E, Timmer M, Bloem BR, Toni I, & Helmich RC. Dopamine controls Parkinson’s tremor by inhibiting the cerebellar thalamus (2017). Brain, in press.

Zach H, Dirkx MF, Pasman J, Bloem BR, Helmich RC. The patient’s perspective: the effect of levodopa on Parkinson symptoms (2017). Parkinsonism & Related Disorders, in press.

Zach H, Dirkx MF, Pasman JW, Bloem BR, Helmich RC. Cognitive Stress Reduces the Effect of Levodopa on Parkinson’s Resting Tremor (2017). CNS Neurosci Ther., in press.

Caligiore D, Helmich RC, Hallett M, Moustafa AA, Timmermann L, Toni I, & Baldassarre G. Parkinson’s disease as a system-level disorder (2017). npj Parkinson’s Disease, in press.

Thaler A, Bregman N, Mirelman A, Helmich RC, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N. A cognitive fMRI study in non-manifesting LRRK2 and GBA-carriers (2016). Brain Structure and Function, in press. 

Caligiore D, Pezzulo G, Baldassarre G, Bostan AC, Strick PL, Doya K, Helmich RC, Dirkx M, Houk J, Jörntell H, Lago-Rodriguez A, Galea JM, Miall RC, Popa T, Kishore A, Verschure PF, Zucca R, Herreros I. Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex (2016). Cerebellum, in press. 

Nonnekes J, Timmer M, De Vries NM, Rascol O, Helmich RC, Bloem BR. Unmasking levodopa resistance in Parkinson’s disease (2016). Mov Disord., 31(11):1602-1609.

Dirkx MF, den Ouden H, Aarts E, Timmer M, Bloem BR, Toni I, Helmich RC. The Cerebral Network of Parkinson’s Tremor: An Effective Connectivity fMRI Study (2016). J Neurosci. 36(19):5362-72.


Hopfner F, Haubenberger D, Galpern WR, Gwinn K, Van’t Veer A, White S, Bhatia K, Adler CH, Eidelberg D, Ondo W, Stebbins GT, Tanner CM, Helmich RC, Lenz FA, Sillitoe RV, Vaillancourt D, Vitek JL, Louis ED, Shill HA, Frosch MP, Foroud T, Kuhlenbäumer G, Singleton A, Testa CM, Hallett M, Elble R, Deuschl G. Knowledge gaps and research recommendations for essential tremor (2016). Parkinsonism Relat Disord. 33:27-35.

Thaler A, Helmich RC, Or-Borichev A, van Nuenen BF, Shapira-Lichter I, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T, Mirelman A. Intact working memory in non-manifesting LRRK2 carriers – an fMRI study (2016). Eur J Neurosci. 43(1):106-12.

Zach H, Dirkx M, Bloem BR, Helmich RC. The clinical evaluation of Parkinson’s tremor (2015). J Parkinson’s Dis. 5(3):471-4.

Zittel S, Helmich RC, Demiralay C, Munchau A, Baumer T. Normalization of sensorimotor integration by repetitive transcranial magnetic stimulation in cervical dystonia (2015). J Neurol. 262(8):1883-9.

Helmich RC, Thaler A, Van Nuenen BFL, Gurevich T, Mirelman A, Marder KS, Bressman S, Orr-Urtreger A, Giladi N, Bloem BR, Toni I. Reorganization of cortico-striatal circuits in healthy G2019S LRRK2 carriers (2015). Neurology. 84(4):399-406.

Aarts E, Nusselein AA, Smittenaar P, Helmich RC, Bloem BR, Cools R. (2014) Greater striatal responses to medication in Parkinson׳s disease are associated with better task-switching but worse reward performance. Neuropsychologia. 62:390-7.

Thaler A, Artzi M, Mirelman A, Jacob Y, Helmich RC, Van Nuenen BFL, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Hendler T, Giladi N, Ben Bashat D, and the LRRK2 Ashkenazi Jewish consortium. A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson’s disease related G2019S LRRK2 mutation carriers (2014). Mov Disord. 29(6):823-7.

Helmich RC, Toni I, Deuschl G, Bloem BR. The pathophysiology of essential tremor and Parkinson’s tremor (2013). Curr Neurol Neurosci Rep. 13(9):378.

Helmich RC. The distributed somatotopy of tremor: a window into the motor system (2012). Exp Neurol, 241:156-8.

Thaler A, Mirelman A, Helmich RC, Van Nuenen BFL, Rosenberg K, Gurevich T, Orr-Urtreger A, Marder K, Bressman S, Bloem BR, Giladi N, Hendler T. Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers (2013). Cortex, 49(9):2501-11.

Delnooz CCS, Helmich RC, Medendorp WP, Van de Warrenburg BPC, Toni I. (2012) Writer’s cramp: increased dorsal premotor activity during intended writing. Hum Brain Mapp., 34(3):613-25

Van Nuenen BF, Helmich RC, Ferraye M, Thaler A, Hendler T, Orr-Urtreger A, Mirelman A, Bressman S, Marder KS, Giladi N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2-parkinsonism. Brain, 135(Pt 12): 3687-3698.

Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012). Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits? Brain, 135 (Pt 11): 3206-26.

Delnooz CCS, Helmich RC, Toni I, Van de Warrenburg BPC (2012). Reduced parietal connectivity with a premotor writing area in writer’s cramp. Mov Disord., 15;27(11): 1425-31

Van Nuenen BF, Helmich RC, Buenen N, Van de Warrenburg BP, Bloem BR, Toni I (2012). Compensatory activity in the extrastriate body area of Parkinson’s disease patients. J Neurosci. 32(28):9546-53.

Helmich RC, Bloem BR, Toni I. (2012) Motor imagery evokes increased somatosensory activity in Parkinson’s disease patients with tremor. Hum Brain Mapp., 33(8):1763-79

Aarts E, Helmich RC, Janssen MJ, Oyen WJ, Bloem BR, Cools R (2011). Aberrant reward processing in Parkinson’s disease is associated with dopamine cell loss. Neuroimage, 5;59(4): 3339-3346.

Helmich RC, Janssen MJR, Oyen WJG, Bloem BR, Toni I. (2011) Pallidal dysfunction drives a cerebello-thalamic circuit into Parkinson tremor. Ann Neurol., 69(2): 269-81.

Helmich RC, Siebner HR, Giffin N, Bestmann S, Rothwell JC, Bloem BR. (2010) The dynamic regulation of cortical excitability is altered in episodic ataxia type 2. Brain. 133(Pt 12): 3519-29.

Snijders AH, Leunissen I, Bakker M, Overeem S, Helmich RC, Bloem BR, Toni I. (2011). Gait-related cerebral alterations in patients with Parkinson’s disease with freezing of gait. Brain. 134(Pt 1): 59-72.

Haaxma CA, Helmich RC, Borm GF, Kappelle AC, Horstink MW, Bloem BR. (2010) Side of symptom onset affects motor dysfunction in Parkinson’s disease. Neuroscience, 10;170(4): 1282-5.

Aarts E, Roelofs A, Franke B, Rijpkema M, Fernandez G, Helmich RC, Cools R (2010). Striatal Dopamine Mediates the Interface between Motivational and Cognitive Control in Humans: Evidence from Genetic Imaging. Neuropsychopharmacology, 35(9): 1943-51.

Helmich RC, Derikx L, Bakker M, Scheeringa R, Bloem BR, & Toni I (2010). Spatial remapping of cortico-striatal connectivity in Parkinson’s disease. Cerebral Cortex, 20(5): 1175-86.

Helmich RC, Aarts E, de Lange, FP, Bloem BR, & Toni I. (2009). Increased dependence of action selection on recent motor history in Parkinson’s disease. J Neurosci, 29: 6105-6113.

Helmich RC, van Laarhoven HW, Schoonderwaldt HC, Janssen MC (2008) Ischemic neuropathy and rhabdomyolysis as presenting symptoms of postpartum cardiomyopathy. J Thromb Thrombolysis, 27: 458-460.

Bakker M, De Lange FP, Helmich RC, Scheeringa R, Bloem BR, Toni I (2008) Cerebral correlates of motor imagery of normal and precision gait. Neuroimage 41: 998-1010.

Helmich RC, de Lange, FP, Bloem, BR, & Toni, I. (2007). Cerebral compensation during motor imagery in Parkinson’s disease. Neuropsychologia, 45: 2201-2215.

Baumer T, Demiralay C, Hidding U, Bikmullina R, Helmich RC, Wunderlich S. Liepert J, Siebner HR, Munchau A. (2007). Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer’s cramp. Mov Disord., 22: 81-90.

De Lange FP, Helmich RC & Toni I (2006). Posture influences motor imagery: an fMRI study. Neuroimage, 33: 609-617.

Helmich RC, Siebner HR, Bakker M, Münchau A, Bloem BR. (2006) Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson’s disease. J. Neurol. Sci., 248: 84-96.

Helmich RC, Baumer T, Siebner HR, Bloem BR, Munchau A (2005) Hemispheric asymmetry and somatotopy of afferent inhibition in healthy humans. Exp. Brain Res., 167: 211-219.

Helmich RC, Snijders AH, Verkes RJ, Bloem BR (2004) Repetitieve transcraniële magnetische stimulatie bij depressie: stimulatie van het brein om de psyche te genezen. Ned Tijdschr Geneeskd, 148: 410-415.

Book chapters

Helmich RC. The pathophysiology of tremor. In: Parkinson disease and other movement disorders (2014). Wolters & Baumann, VU University Press, Amsterdam.



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